ZFP36L1/ERF1 Rabbit anti-Human, Polyclonal, Bioss

Rabbit Polyclonal Antibody

Supplier:  Bioss BS12254R

Catalog No. 50-198-2078

Description

RNA polymerase (pol) III synthesizes tRNA, 5s rRNA, 7SL RNA and U6 snRNA and is overexpressed in many transformed cell lines and tumors in vivo, since cells must duplicate its protein components before division. Therefore, in order to maintain rapid growth, cells must produce a high level of Pol III transcribed RNA, which requires the presence of the TFIIIB and TFIIIC2 transcription factor complexes. The TFIIIC2 complex is composed of five subunits, TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, that are overexpressed in adenovirus transformed cells as well as in malignant cells in vivo, such as ovarian carcinomas. TFIIIC2 recruits RNA pol III and TFIIIB to promoter elements and may be a key component in the deregulation of malignant cells. The TFIIIB complex includes the TATA-binding protein (TBP), TFIIB-related factor 1 (TFIIIB90, BRF1) and TFIIIB, the expression of which are also upregulated in transformed cells. In many carcinomas, the tumor suppressors retinoblastoma (RB) and p53 are inactivated, which affects their ability to bind and inactivate the function of TFIIIB.

Specifications

• Antigen: ZFP36L1/ERF1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BRF1
• Gene Alias: 2510002F24Rik; B - related factor 1; B-related factor 1; BRF; BRF1; BRF-1; BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB; BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae); BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit; BRF1, RNA polymerase III transcription initiation factor 90 subunit; CFDS; epididymis secretory sperm binding protein Li 76p; general transcription factor IIIB, 90kD subunit; GTF3B; hBRF; HEL-S-76p; hTFIIIB90; mTFIIIB90; PCF4; TAF3B2; TAF3C; TAFIII90; TATA box binding protein (TBP)-associated factor 3C; TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 2; TATA box-binding protein-associated factor, RNA polymerase III, subunit 2; TBP - associated factor, RNA polymerase III, 90kD; TDS4; TF3B90; TFIIIB; TFIIIB90; Transcription factor IIIB 70 kDa subunit; Transcription factor IIIB 90 kDa subunit; transcription factor TFIIIB subunit BRF1; YGR246C; ZFP36L1; zinc finger protein 36, C3H type-like 1
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 2972
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 μg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene Accession No.: Q92994
• Gene Symbols: BRF1
• Immunogen: KLH conjugated synthetic peptide derived from human ZFP36L1/ERF1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG