Invitrogen™ ZFYVE19 Monoclonal Antibody (3G4-2B11)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA522803

Catalog No. PIMA522803

Description

Peptide Sequence: MESRCYGCAV KFTLFKKEYG CKNCGRAFCS GCLSFSAAVP RTGNTQQKVC KQCHEVLTRG SSANASKWSP PQNYKKRVAA LEAKQKPSTS QSQGLTRQDQ MIAERLARLR QENKPKLVPS QAEIEARLAA LKDERQGSIP STQEMEARLA ALQGRVLPSQ TPQPAHHTPD TRTQAQQTQD LLTQLAAEVA IDESWKGGGP AASLQNDLNQ GGPGSTNSKR QANWSLEEEK SRLLAEAALE LREENTRQER ILALAKRLAM LRGQDPERVT LQDYRLPDSD DDEDEETAIQ RVLQQLTEEA ALDEASGFNI PAEQASRPWT QPRGAEPEAQ DVDPRPEAEE EELPWCCICN EDATLRCAGC DGDLFCARCF REGHDAFELK EHQTSAYSPP RAGQEH.

Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.

Specifications

• Antigen: ZFYVE19
• Classification: Monoclonal
• Concentration: 1.0 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: Q96K21
• Gene Symbols: ZFYVE19
• Immunogen: ZFYVE19 (AAH15738.1, 1 a.a. ~ 396 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b κ

• Applications: ELISA, Immunoprecipitation, Western Blot
• Clone: 3G4-2B11
• Conjugate: Unconjugated
• Gene: ZFYVE19
• Gene Alias: 1500041L05Rik; abscission/NoCut checkpoint regulator; ANCHR; MLL partner containing FYVE domain; MPFYVE; Zfyve19; Zinc finger FYVE domain-containing protein 19; zinc finger FYVE-type containing 19; zinc finger, FYVE domain containing 19
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 84936
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid