ZFYVE21 Mouse anti-Human, Clone: OTI4A2, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF505622

Catalog No. 50-166-3784

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

ZF21 was initially identified as protein that could bind to the cytoplasmic tail of MT1-MMP (Membrane-type 1 matrix metalloproteinase), a potent invasion-promoting protease. ZF21 is a member of a protein family characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain and regulates focal adhesions (FAs) and cell movement. Knockdown of ZF21 expression resulted in a delay of FA disassembly following induction of synchronous disassembly of FAs by nocodazole treatment, suggesting that ZF21 is involved in FA disassembly. ZF21 contains a noncanonical pleckstrin homology domain that is a possible therapeutic target to treat metastatic cancer.

Specifications

• Antigen: ZFYVE21
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: ZFYVE21
• Gene Alias: HCVP7TP1, ZF21
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 79038
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI4A2
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q9BQ24
• Gene Symbols: ZFYVE21
• Immunogen: Full length human recombit protein of human ZFYVE21 produced in HEK293T cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1