Invitrogen™ ZFYVE26 Polyclonal Antibody

Catalog No.	Quantity
PIPA563138	100 μL

Catalog No. PIPA563138 Supplier Invitrogen™ Supplier No. PA563138

Description

Rabbit Polyclonal Antibody

Immunogen sequence: DSSKNESPPY SFVVRVPKAD EVEWILDLKE EENELVRSEF YYEQAPSASL CIAILNLHRD SIACGHQLIE HCCRLSKGLT NPEVDAGLL Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 91%.

Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders. Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia in which mental retardation and muscle stiffness at onset are followed by slowly progressive paraparesis and cognitive deterioration. SPG15 is the second gene known to be responsible for ARHSP-TCC in the Italian population. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. SPG15 encodes a protein containing a FYVE zinc finger binding domain which is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. SPG15 mRNA is widely distributed in human tissues, as well as in rat embryos, suggesting a possible role for this protein during embryonic development. SPG15 co-localizes partially with endoplasmic reticulum and endosome markers, suggesting a role in intracellular trafficking. Multiple isoforms of SPG15 are known to exist.

Specifications

• Antigen: ZFYVE26
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 0.05 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: ZFYVE26
• Gene Accession No.: Q68DK2
• Gene Alias: 4930465A13; 9330197E15Rik; A630028O16Rik; FYVE domain-containing centrosomal protein; FYVE-CENT; Gm893; Kiaa0321; mKIAA0321; Spastizin; SPG15; Zfyve26; Zinc finger FYVE domain-containing protein 26; zinc finger FYVE-type containing 26; zinc finger, FYVE domain containing 26
• Gene Symbols: ZFYVE26
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human ZFYVE26. Recombinant protein control fragment (Product #RP-101111).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 23503
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG