ZHX2 Monoclonal Antibody (OTI2E11), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA527337

Catalog No. PIMA527337

Description

Zinc-fingers and homeobox (ZHX) proteins are transcription factors that interact with the activation domain of the A subunit of nuclear factor-Y (NF-YA). ZHX1-3 are ubiquitously expressed proteins expressed in various tissues. They act as transcriptional repressors and localize to the nucleus. The ZHX proteins contain two Cys(2)-His(2)-type zinc-finger motifs and five homeodomains (HDs). These domains allow the ZHX proteins to form homodimers, but they can also form heterodimers with each other. However, this dimerization is not required for repressor activity. Hypermethylation-mediated silencing of ZHX2 is an epigenetic event involved in hepatocellular carcinoma (HCC).

Specifications

• Antigen: ZHX2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q8C0C0, Q9Y6X8
• Gene Symbols: ZHX2
• Immunogen: Human recombinant protein fragment corresponding to amino acids 595-837 of ZHX2 produced in E.coli
• Quantity: 100μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI2E11
• Conjugate: Unconjugated
• Gene: ZHX2
• Gene Alias: AFP regulator 1; AFR1; Afr-1; alpha fetoprotein regulation 1, adult; alpha-fetoprotein regulator 1; KIAA0854; LOW QUALITY PROTEIN: zinc fingers and homeoboxes protein 2; mKIAA0854; Raf; Regulator of AFP; transcription factor ZHX2; Zhx2; Zinc finger and homeodomain protein 2; zinc fingers and homeoboxes 2; zinc fingers and homeoboxes protein 2; zinc-fingers and homeoboxes 2
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22882, 387609
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid