Invitrogen™ ZHX2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120626

Catalog No. PIPA5120626

Description

Positive test controls include: U-251MG, 293T, Raji, LO2, Mouse brain. Immunogen sequence: SDHRYRCQRG IVHITSESLA KDQLAIAASR HGRTYHAYPD FAPQKFKEKT QGQVKILEDS FLKSSFPTQA ELDRLRVETK LSRREIDSWF SERRKLRDSM EQAVLDSMGS GKKGQDVGAP NGALSRLDQL SGAQLTSSLP SPSPAIAKSQ EQVHLLRSTF ARTQWPTPQE YDQLAAKTGL VRTEIVRWFK ENRCLLKTGT VKWMEQYQHQ PMADDHGYDA VARKATKPMA ESPKNGGDVV PQYYKDPKKL CEEDLEKLVT RVKVGSEPAK DCLPAKPSEA TSDRSEGSSR DGQGSDENEE SSVVDYVEVT VGEEDAISDR SDSWSQAAAE GVSELAESDS DCVPAEAGQA.

Zinc-fingers and homeobox (ZHX) proteins are transcription factors that interact with the activation domain of the A subunit of nuclear factor-Y (NF-YA). ZHX1-3 are ubiquitously expressed proteins expressed in various tissues. They act as transcriptional repressors and localize to the nucleus. The ZHX proteins contain two Cys(2)-His(2)-type zinc-finger motifs and five homeodomains (HDs). These domains allow the ZHX proteins to form homodimers, but they can also form heterodimers with each other. However, this dimerization is not required for repressor activity. Hypermethylation-mediated silencing of ZHX2 is an epigenetic event involved in hepatocellular carcinoma (HCC).

Specifications

• Antigen: ZHX2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZHX2
• Gene Alias: AFP regulator 1; AFR1; Afr-1; alpha fetoprotein regulation 1, adult; alpha-fetoprotein regulator 1; KIAA0854; LOW QUALITY PROTEIN: zinc fingers and homeoboxes protein 2; mKIAA0854; Raf; Regulator of AFP; transcription factor ZHX2; Zhx2; Zinc finger and homeodomain protein 2; zinc fingers and homeoboxes 2; zinc fingers and homeoboxes protein 2; zinc-fingers and homeoboxes 2
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22882, 314988, 387609
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.33 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q80VX4, Q8C0C0, Q9Y6X8
• Gene Symbols: ZHX2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 488-837 of human ZHX2 (NP_055758.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG