Invitrogen™ ZHX2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA522217

Catalog No. PIPA522217

Description

Recommended positive controls: A431, H1299, HeLa, HepG2, Molt-4, Raji. Predicted reactivity: Bovine (80%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Zinc-fingers and homeobox (ZHX) proteins are transcription factors that interact with the activation domain of the A subunit of nuclear factor-Y (NF-YA). ZHX1-3 are ubiquitously expressed proteins expressed in various tissues. They act as transcriptional repressors and localize to the nucleus. The ZHX proteins contain two Cys(2)-His(2)-type zinc-finger motifs and five homeodomains (HDs). These domains allow the ZHX proteins to form homodimers, but they can also form heterodimers with each other. However, this dimerization is not required for repressor activity. Hypermethylation-mediated silencing of ZHX2 is an epigenetic event involved in hepatocellular carcinoma (HCC).

Specifications

• Antigen: ZHX2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZHX2
• Gene Alias: AFP regulator 1; AFR1; Afr-1; alpha fetoprotein regulation 1, adult; alpha-fetoprotein regulator 1; KIAA0854; LOW QUALITY PROTEIN: zinc fingers and homeoboxes protein 2; mKIAA0854; Raf; Regulator of AFP; transcription factor ZHX2; Zhx2; Zinc finger and homeodomain protein 2; zinc fingers and homeoboxes 2; zinc fingers and homeoboxes protein 2; zinc-fingers and homeoboxes 2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22882
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ChIP sequencing (ChIP-seq), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Concentration: 0.70 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: Q9Y6X8
• Gene Symbols: ZHX2
• Immunogen: Recombinant fragment corresponding to a region within amino acids 533 and 826 of ZHX2 (Uniprot ID#Q9Y6X8).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov