ZIC-2Rabbit anti-Canine, Chimpanzee, Human, Mouse, Rat, Polyclonal, Rockland™

Catalog No.	Quantity
50-199-1809	100 μg

Catalog No. 50-199-1809 Supplier Rockland Immunochemicals Supplier No. 600401848

Description

Rabbit Polyclonal Antibody

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. This affinity purified antibody is directed against mouse ZIC2 protein. A BLAST analysis was used to suggest reactivity with this protein from human, chimpanzee, mouse, rat and dog based on 100% homology for the immunogen sequence. Expect cross reactivity with ZIC2 from chicken, zebrafish and frog as the core 16 amino acid residues within the immunogen sequence show very high degrees of homology with ZIC2 from these sources. Cross reactivity with ZIC2 homologues from other sources has not been determined.

ZIC2 (zinc finger protein of the cerebellum 2) is a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. In mouse, knockout of Zic1 leads to aplasia of cerebellum and skeletal abnormalities. Mutation in Zic2 and Zic3 in mouse and/or human cause holoprosencephaly and heterotaxis, respectively. Holoprosencephaly is the most common structural anomaly of the human brain.

Specifications

• Antigen: ZIC-2
• Applications: ELISA, Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
• Gene: ZIC2
• Gene Accession No.: O95409, Q62520
• Gene Alias: BOS_12680; cerebellum zinc finger protein 2; GENA 29; HPE5; Ku; kumba; odd-paired homolog; Zic family member 2; Zic family member 2 (odd-paired homolog, Drosophila); ZIC2; Zinc finger protein of the cerebellum 2; Zinc finger protein ZIC 2
• Gene Symbols: ZIC2
• Host Species: Rabbit
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 22772, 361096, 467311, 485533, 7546
• Target Species: Canine, Chimpanzee, Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid