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Invitrogen™ Zika Virus Envelope (Domain III) (strain Zika SPH2015) Recombinant Rabbit Monoclonal Antibody (033)
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Catalog No. PIMA530002
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100 μL
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PIMA530002 100 μL
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Catalog No. PIMA530002 Supplier Invitrogen™ Supplier No. MA530002
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Description

Rabbit Recombinant Monoclonal Antibody

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire. This antibody has specificity for Zika virus (ZIKV) (strain Zika SPH2015) ZIKV-E/Envelope protein (Domain III).

As a member of the Flaviviridae family, ZIKV has a single positive sense RNA genome, which is initially translated as a single polyprotein which is then cleaved post-transitionally into three structural proteins (C, PrM or M, and E) and seven nonstructural (NS) proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5)(1). The glycosated NS1 forms a homodimer inside the cells and is necessary for viral replication and late in infection (2). NS1 is also secreted into the extracellular space as a hexameric lipoprotein particle, which assists the virus in immune evasion and pathogenesis by interacting with components from both innate and adaptive immune systems as well as other host factors (1). Reference 1) Song, H.; Qi, J.; Haywood, J.; Shi, Y.; Gao, G.F. (2016). Nat. Struct. Mol. Biol. 23, 456-458. 2) Suthar, M.S., Diamond, M.S. and Gale, M. Jr. (2013). Nat. Rev. Microbiol. 11, 115-128.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Zika Virus Envelope (Domain III) (strain Zika SPH2015)
Applications ELISA
Classification Recombinant Monoclonal
Clone 033
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene Alias Zika Envelope
Host Species Rabbit
Immunogen Recombinant Zika virus (ZIKV) (strain Zika SPH2015) ZIKV-E/Envelope protein (Domain III) Protein.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Target Species Virus
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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