Invitrogen™ Zika Virus Envelope Protein Monoclonal Antibody (6932)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA533303

Catalog No. PIMA533303

Description

Does not cross react with the following viruses: Dengue 1-4, and Chikungunya virus.

As a member of the Flaviviridae family, ZIKV has a single positive sense RNA genome, which is initially translated as a single polyprotein which is then cleaved post-transitionally into three structural proteins (C, PrM or M, and E) and seven nonstructural (NS) proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5)(1). The glycosated NS1 forms a homodimer inside the cells and is necessary for viral replication and late in infection (2). NS1 is also secreted into the extracellular space as a hexameric lipoprotein particle, which assists the virus in immune evasion and pathogenesis by interacting with components from both innate and adaptive immune systems as well as other host factors (1). Reference 1) Song, H.; Qi, J.; Haywood, J.; Shi, Y.; Gao, G.F. (2016). Nat. Struct. Mol. Biol. 23, 456-458. 2) Suthar, M.S., Diamond, M.S. and Gale, M. Jr. (2013). Nat. Rev. Microbiol. 11, 115-128.

Specifications

• Antigen: Zika Virus Envelope Protein
• Classification: Monoclonal
• Concentration: 100 μg/mL
• Formulation: PBS with 0.1% sodium azide; pH 7.2
• Host Species: Mouse
• Quantity: 1 mL
• Primary or Secondary: Primary
• Content And Storage: 4°C
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Clone: 6932
• Conjugate: Unconjugated
• Gene Alias: Zika Envelope
• Purification Method: Protein A
• Regulatory Status: RUO
• Target Species: Virus
• Product Type: Antibody
• Isotype: IgG2b

Safety and Handling

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