Invitrogen™ Zika Virus Envelope (strain Zika SPH2015) Monoclonal Antibody (35)

Catalog No.	Quantity
PIMA530023	100 μL

Catalog No. PIMA530023 Supplier Invitrogen™ Supplier No. MA530023

Description

Mouse Monoclonal Antibody

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). This antibody has specificity for Zika virus (strain Zika SPH2015) Envelope Protein (ZIKV-E).

As a member of the Flaviviridae family, ZIKV has a single positive sense RNA genome, which is initially translated as a single polyprotein which is then cleaved post-transitionally into three structural proteins (C, PrM or M, and E) and seven nonstructural (NS) proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5)(1). The glycosated NS1 forms a homodimer inside the cells and is necessary for viral replication and late in infection (2). NS1 is also secreted into the extracellular space as a hexameric lipoprotein particle, which assists the virus in immune evasion and pathogenesis by interacting with components from both innate and adaptive immune systems as well as other host factors (1). Reference 1) Song, H.; Qi, J.; Haywood, J.; Shi, Y.; Gao, G.F. (2016). Nat. Struct. Mol. Biol. 23, 456-458. 2) Suthar, M.S., Diamond, M.S. and Gale, M. Jr. (2013). Nat. Rev. Microbiol. 11, 115-128.

Specifications

• Antigen: Zika Virus Envelope (strain Zika SPH2015)
• Applications: ELISA
• Classification: Monoclonal
• Clone: 35
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with no preservative
• Gene Alias: Zika Envelope
• Host Species: Mouse
• Immunogen: Recombinant Zika virus (strain Zika SPH2015) Envelope Protein (ZIKV-E) Protein.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Virus
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid