Invitrogen™ Zika Virus NS1 Monoclonal Antibody (EA23)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA524582

Catalog No. PIMA524582

Description

MA5-24582 does not cross react with the following viruses: Dengue 1-4, TBE virus, West Nile virus, Yellow Fever virus, Japanese Encephalitis virus and Chikungunya virus.

As a member of the Flaviviridae family, ZIKV has a single positive sense RNA genome, which is initially translated as a single polyprotein which is then cleaved post-transitionally into three structural proteins (C, PrM or M, and E) and seven nonstructural (NS) proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5)(1). The glycosated NS1 forms a homodimer inside the cells and is necessary for viral replication and late in infection (2). NS1 is also secreted into the extracellular space as a hexameric lipoprotein particle, which assists the virus in immune evasion and pathogenesis by interacting with components from both innate and adaptive immune systems as well as other host factors (1). Reference 1) Song, H.; Qi, J.; Haywood, J.; Shi, Y.; Gao, G.F. (2016). Nat. Struct. Mol. Biol. 23, 456-458. 2) Suthar, M.S., Diamond, M.S. & Gale, M. Jr. (2013). Nat. Rev. Microbiol. 11, 115-128.

Specifications

• Antigen: Zika Virus NS1
• Classification: Monoclonal
• Concentration: 100 μg/mL
• Formulation: PBS with 0.1% sodium azide; pH 7.2
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Target Species: Virus
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Immunocytochemistry
• Clone: EA23
• Conjugate: Unconjugated
• Gene Alias: Zika NS1; ZIKV NS1; ZIKV-NS1
• Immunogen: recombinant Zika Virus NS1 protien.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Content And Storage: 4°C
• Form: Liquid