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Invitrogen™ Zika Virus NS1 (strain H/PF/2013) Polyclonal Antibody

Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA5143434
Description
Store as concentrated solution. Centrifuge briefly prior to opening vial. Positive control: Zika virus NS1-transfected 293T.
As a member of the Flaviviridae family, ZIKV has a single positive sense RNA genome, which is initially translated as a single polyprotein which is then cleaved post-transitionally into three structural proteins (C, PrM or M, and E) and seven nonstructural (NS) proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5)(1). The glycosated NS1 forms a homodimer inside the cells and is necessary for viral replication and late in infection (2). NS1 is also secreted into the extracellular space as a hexameric lipoprotein particle, which assists the virus in immune evasion and pathogenesis by interacting with components from both innate and adaptive immune systems as well as other host factors (1). Reference 1) Song, H.; Qi, J.; Haywood, J.; Shi, Y.; Gao, G.F. (2016). Nat. Struct. Mol. Biol. 23, 456-458. 2) Suthar, M.S., Diamond, M.S. & Gale, M. Jr. (2013). Nat. Rev. Microbiol. 11, 115-128.
Specifications
Zika Virus NS1 (strain H/PF/2013) | |
Polyclonal | |
Unconjugated | |
Zika NS1; ZIKV NS1; ZIKV-NS1 | |
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of Zika virus NS1 protein (Zika virus (strain H/PF/2013)). The exact sequence is proprietary. | |
100 μL | |
Primary | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
ELISA, Western Blot, Immunocytochemistry | |
1 mg/mL | |
PBS with 20% glycerol and 0.025% Proclin 300; pH 7 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
Virus | |
Antibody | |
IgG |
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