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Invitrogen™ Zika Virus NS3 (strain H/PF/2013) Polyclonal Antibody
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Catalog No. PIPA5143436
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100 μL
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PIPA5143436 100 μL
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Catalog No. PIPA5143436 Supplier Invitrogen™ Supplier No. PA5143436
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Description

Rabbit Polyclonal Antibody

Store as concentrated solution. Centrifuge briefly prior to opening vial.

Zika virus is a flavivirus discovered in 1947, but the association between Zika virus infection and brain disorders was not demonstrated until 2015 in Brazil. Infection mostly poses a threat to women during pregnancy, since it may cause microcephaly and other neurological dysfunctions in the developing fetus. ZIKV NS3 expression alone may induce BMP2 maturation, osteogenic gene expression and calcification, but purified NS3 protease has been reported to effectively cleave pro-BMP2 in vitro to generate biologically active mature BMP2. These findings highlight ZIKV-induced calcification where the NS3 protease subverts the BMP2-mediated osteogenic signalling pathway to trigger brain calcification. The nonstructural NS3 protein is essential for virus replication because it helps to remodel the cellular microenvironment. Several reports show that this protease can process cellular substrates and thereby modify cellular pathways that are important for the virus.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Zika Virus NS3 (strain H/PF/2013)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.025% Proclin 300; pH 7
Gene Alias NS3 protease; Zika NS3 protease; Zika Virus NS3 protease
Host Species Rabbit
Immunogen Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of Zika virus NS3 protein (Zika virus (strain H/PF/2013)). The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Target Species Virus
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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