Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. PIPA5143381

Invitrogen™ Zika Virus NS3 (strain H/PF/2013) Polyclonal Antibody
GREENER_CHOICE

Catalog No. PIPA5143381
Change view
Click to view available options
Quantity:
100 μL
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
PIPA5143381 100 μL
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. PIPA5143381 Supplier Invitrogen™ Supplier No. PA5143381
Add to Cart
Add to Cart

Description

Rabbit Polyclonal Antibody

Store as concentrated solution. Centrifuge briefly prior to opening vial. Positive control: Zika-infected Vero.

Zika virus is a flavivirus discovered in 1947, but the association between Zika virus infection and brain disorders was not demonstrated until 2015 in Brazil. Infection mostly poses a threat to women during pregnancy, since it may cause microcephaly and other neurological dysfunctions in the developing fetus. ZIKV NS3 expression alone may induce BMP2 maturation, osteogenic gene expression and calcification, but purified NS3 protease has been reported to effectively cleave pro-BMP2 in vitro to generate biologically active mature BMP2. These findings highlight ZIKV-induced calcification where the NS3 protease subverts the BMP2-mediated osteogenic signalling pathway to trigger brain calcification. The nonstructural NS3 protein is essential for virus replication because it helps to remodel the cellular microenvironment. Several reports show that this protease can process cellular substrates and thereby modify cellular pathways that are important for the virus.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Zika Virus NS3 (strain H/PF/2013)
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.35 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.025% Proclin 300; pH 7
Gene Alias NS3 protease; Zika NS3 protease; Zika Virus NS3 protease
Host Species Rabbit
Immunogen Full length Zika virus NS3 recombinant protein. (Zika virus (strain H/PF/2013)).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Target Species Virus
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.