Invitrogen™ ZIPK Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA527700

Catalog No. PIPA527700

Description

Recommended positive controls: A549. Predicted reactivity: Mouse (96%), Rat (96%), Xenopus laevis (87%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (99%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

DAPK3 is a serine/threonine kinase which is functionally linked to cell motility, smooth muscle contractility and cell death processes. DAPK3 is encoded by ZIPK and is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.

Specifications

• Antigen: ZIPK
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DAPK3
• Gene Alias: DAP kinase 3; DAP3K; Dapk3; Dapkl; DAP-like kinase; death associated protein kinase 3; death-associated kinase 3; Death-associated like kinase; death-associated protein kinase 3; DLK; MYPT1 kinase; ZIP; ZIP kinase; ZIP kinase isoform; Zipk; ZIP-kinase; zipper-interacting protein kinase
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13144, 1613, 64391
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.61 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: O43293, O54784, O88764
• Gene Symbols: DAPK3
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 172 of Human DAP kinase 3.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov