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  5. Tocris Bioscience™ ZJ 43

Tocris Bioscience™ ZJ 43

Catalog No. 267510
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10 mg
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26-751-0 10 mg
26-751-R 1 mg
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Catalog No. 26-751-0 Supplier Tocris Bioscience™ Supplier No. 2675/10

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Description

Glutamate carboxypeptidase II and III (NAALADase, NAAG peptidase) inhibitor

ZJ 43 is a potent inhibitor of glutamate carboxypeptidase II and III (GCP II and III/NAAG peptidase/NAALADase) (Ki values are 0.8 and 23 nM respectively) that inhibits the hydrolysis of NAAG (IC50 = 2.4 nM) . Does not directly interact with NMDA or metabotropic glutamate receptors. Reduces neuronal degeneration in a rat model of traumatic brain injury (TBI) and reduces locomotor activity in the PCP-model of schizophrenia.

Specifications

Chemical Name or Material N-[[[(1 S)-1-Carboxy-3-methylbutyl]amino]carbonyl]-L-glutamic acid
CAS 723331-20-2
Quantity 10 mg
Solubility Soluble to 100mM in DMSO
Target Carboxypeptidase Inhibitors
Molecular Formula C12H20N2O7
Formula Weight Observed MW: 304.3
Purity 95%

For Research Use Only

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