Invitrogen™ ZMYND10 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA521864

Catalog No. PIPA521864

Description

Recommended positive controls: 293T, A431, H1299, Raji. Predicted reactivity: Mouse (100%), Rat (100%), Chimpanzee (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The ZMYND10 gene encodes a protein that contains a MYND-type zinc finger domain, playing a crucial role in the assembly and function of cilia. Specifically, ZMYND10 is essential for the proper axonemal assembly of both inner and outer dynein arms, which are critical components of motile cilia. Mutations in ZMYND10 are associated with primary ciliary dyskinesia (PCD), a genetic disorder characterized by defective ciliary motility leading to recurrent respiratory infections and male infertility. In model organisms like mice and Drosophila, ZMYND10 expression is restricted to tissues and cells with motile cilia, such as chordotonal sensory neurons and sperm cells. Additionally, ZMYND10 has been identified as an epigenetically regulated tumor suppressor in various cancers, with its downregulation affecting processes like cell proliferation and tumor progression. The gene's dual role in ciliary function and tumorigenesis underlines its importance in both normal cellular physiology and disease pathology.

Specifications

• Antigen: ZMYND10
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Zmynd10
• Gene Alias: Blu; CILD22; FLU; LUCA12.4; Protein BLu; zinc finger MYND domain-containing protein 10; zinc finger MYND-type containing 10; zinc finger, MYND domain containing 10; zinc finger, MYND domain-containing 10; zinc finger, MYND-type containing 10; Zmynd10
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51364
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: O75800
• Gene Symbols: Zmynd10
• Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human BLU. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov