Invitrogen™ ZNF692 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA566533

Catalog No. PIPA566533

Description

Immunogen sequence: ASTGSQAQSAP TPAWDEDTAQ IGPKRIRKAA KRELMPCDFP GCGRIFSNRQ YLNHHKKYQH IHQKSFSCP Highest antigen sequence identity to the following orthologs - mouse 90%, rat 89%.

ZNF692, a zinc finger protein, is involved in several cellular processes including nucleolar organization and ribosome biogenesis. It interacts with nucleophosmin (NPM1), regulating nucleolar morphology by modifying NPM1's self-assembly properties and influencing protein synthesis. Knockdown of ZNF692 causes nucleolar redistribution of NPM1 and results in a decreased rate of protein synthesis. Additionally, ZNF692 plays a role in 40S ribosomal subunit maturation by forming a hub with the exosome complex and ribosome biogenesis factors. This gene is upregulated in certain cancers such as clear cell renal cell carcinoma (ccRCC), where its expression is associated with increased cell proliferation, migration, and poor overall survival.

Specifications

• Antigen: ZNF692
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZNF692
• Gene Alias: AICAR responsive element binding protein; AREBP; Zfp692; zinc finger protein 692; ZNF692
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55657
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9BU19
• Gene Symbols: ZNF692
• Immunogen: Recombinant Human ZN692. Recombinant protein control fragment (Product #RP-105243).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov