Invitrogen™ ZNF281 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA521121

Catalog No. PIPA521121

Description

A suggested positive control is A-20 cell lysate. PA5-21121 can be used with blocking peptide PEP-1235.

ZFP281, also known as ZBP-99, is a member of a conserved family of transcription factors that interact with GC-rich promoters. It contains four Kruppel-like zinc fingers and is highly homologous to ZBP-89, another regulator of ornithine decarboxylase gene expression. ZFP281 also interacts with many other other transcription factors, such as Sp1 to repress vimentin gene transcription. ZFP281 has also been shown to control embryonic stem cell pluripotency by direct regulating specific target genes. ZFP281 phyically interacts with the transcription factos POU5F1, Sox2, and NANOG. Gene expression microarray anlysis indicated that some ZFP281 target genes were activated, while others were repressed upon knockdown of ZFP281 expression, showing that ZFP281 plays bifuctinal roles in regulating gene expression in stem cells.

Specifications

• Antigen: ZNF281
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZNF281
• Gene Alias: GC-box-binding zinc finger protein 1; GZP1; Transcription factor ZBP-99; ZBP99; ZBP-99; Zfp281; Zinc finger DNA-binding protein 99; zinc finger protein 281; ZNF281; ZNP-99; ZNP-99 transcription factor
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 226442, 23528
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q99LI5, Q9Y2X9
• Gene Symbols: Zfp281, ZNF281
• Immunogen: A 19 amino acid peptide near the carboxy terminus of human ZFP281.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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