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Invitrogen™ ZNF350 Polyclonal Antibody
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Catalog No. PIPA581951
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PIPA581951 100 μL
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Catalog No. PIPA581951 Supplier Invitrogen™ Supplier No. PA581951
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: FKLEQGEQLW TIEDGIHSGA CSDIWKVDHV LERLQSESLV NRRKPCHEHD AFENIVHCSK SQFLLGQNHD IFDLRGKSLK SNLTLVNQSK GYEIKNSVEF TGNGDSFLHA NHERLHTAIK FPASQ Highest antigen sequence indentity to the following orthologs: Mouse - 25%, Rat - 25%.

ZBRK1 is a member of the Kruppel-associated box-zinc finger protein (KRAB-ZFP) protein family of transcriptional repressors. ZBRK1 has been shown to not only be up-regulated in senescent fibroblasts but also interacts with BRCA1, a transcriptional regulator with tumor suppressor activity. ZBRK1 binds to a specific sequence within the GADD45 gene, supporting the assembly of a nuclear complex containing BRCA1 and repressing its transcription. Recent experiments demonstrate that ZBRK1 can homo-oligomerize in vitro and in vivo through a C-terminal transcriptional repression domain (CTRD), and this oligomerization facilitates the ZBRK1-directed transcriptional repression through ZBRK1 response elements. These results suggest that higher order ZBRK1 oligomers may assemble through both protein-DNA and CTRD-dependent protein-protein interactions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZNF350
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ZNF350
Gene Accession No. Q9GZX5
Gene Alias KRAB zinc finger protein ZFQR; ZBRK1; ZFQR; Zinc finger and BRCA1-interacting protein with a KRAB domain 1; zinc finger protein 350; Zinc finger protein ZBRK1; zinc-finger protein ZBRK1; ZNF350
Gene Symbols ZNF350
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human ZNF350. Recombinant protein control fragment (Product #RP-99731).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 59348
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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