Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. PIPA596826

Invitrogen™ ZNF350 Polyclonal Antibody
GREENER_CHOICE

Catalog No. PIPA596826
Change view
Click to view available options
Quantity:
100 μL
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
PIPA596826 100 μL
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. PIPA596826 Supplier Invitrogen™ Supplier No. PA596826
Add to Cart
Add to Cart

Description

Rabbit Polyclonal Antibody

Positive Samples: Jurkat, THP-1, Mouse thymus; Cellular Location: Nucleus, Nucleus matrix Immunogen sequence: TGEKPYICSE CGKGFIQKGN LIVHQRIHTG EKPYICNECG KGFIQKTCLI AHQRFHTGKT PFVCSECGKS CSQKSGLIKH QRIHTGEKPF ECSECGKAFS TKQKLIVHQR THTGERPYGC NECGKAFAYM SCLVKHKRIH TREKQEAAKV ENPPAERHSS LHTSDVMQEK NSANGATTQV PSVAPQTSLN ISGLLANRNV VLVGQPVVRC AASGDNRGFA QDRNLVNAVN VVVPSVINYV LFYVTENP.

ZBRK1 is a member of the Kruppel-associated box-zinc finger protein (KRAB-ZFP) protein family of transcriptional repressors. ZBRK1 has been shown to not only be up-regulated in senescent fibroblasts but also interacts with BRCA1, a transcriptional regulator with tumor suppressor activity. ZBRK1 binds to a specific sequence within the GADD45 gene, supporting the assembly of a nuclear complex containing BRCA1 and repressing its transcription. Recent experiments demonstrate that ZBRK1 can homo-oligomerize in vitro and in vivo through a C-terminal transcriptional repression domain (CTRD), and this oligomerization facilitates the ZBRK1-directed transcriptional repression through ZBRK1 response elements. These results suggest that higher order ZBRK1 oligomers may assemble through both protein-DNA and CTRD-dependent protein-protein interactions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZNF350
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.66 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene ZNF350
Gene Accession No. Q9GZX5
Gene Alias KRAB zinc finger protein ZFQR; ZBRK1; ZFQR; Zinc finger and BRCA1-interacting protein with a KRAB domain 1; zinc finger protein 350; Zinc finger protein ZBRK1; zinc-finger protein ZBRK1; ZNF350
Gene Symbols ZNF350
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 285-532 of human ZNF350 (NP_0676453).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 59348
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
Show More Show Less

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.