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Invitrogen™ ZNF350 Polyclonal Antibody
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Catalog No. PIPA520614
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100 μg
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Catalog No. Quantity
PIPA520614 100 μg
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Catalog No. PIPA520614 Supplier Invitrogen™ Supplier No. PA520614
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Description

Rabbit Polyclonal Antibody

A suggested positive control is A-20 cell lysate. PA5-20614 can be used with blocking peptide PEP-0734.

ZBRK1 is a member of the Kruppel-associated box-zinc finger protein (KRAB-ZFP) protein family of transcriptional repressors. ZBRK1 has been shown to not only be up-regulated in senescent fibroblasts but also interacts with BRCA1, a transcriptional regulator with tumor suppressor activity. ZBRK1 binds to a specific sequence within the GADD45 gene, supporting the assembly of a nuclear complex containing BRCA1 and repressing its transcription. Recent experiments demonstrate that ZBRK1 can homo-oligomerize in vitro and in vivo through a C-terminal transcriptional repression domain (CTRD), and this oligomerization facilitates the ZBRK1-directed transcriptional repression through ZBRK1 response elements. These results suggest that higher order ZBRK1 oligomers may assemble through both protein-DNA and CTRD-dependent protein-protein interactions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZNF350
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene ZNF350
Gene Accession No. Q9GZX5
Gene Alias KRAB zinc finger protein ZFQR; ZBRK1; ZFQR; Zinc finger and BRCA1-interacting protein with a KRAB domain 1; zinc finger protein 350; Zinc finger protein ZBRK1; zinc-finger protein ZBRK1; ZNF350
Gene Symbols ZNF350
Host Species Rabbit
Immunogen A 20 amino acid peptide near the carboxy terminus of the human ZBRK1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 59348
Target Species Human, Mouse, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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