Invitrogen™ ZNF350 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520614

Catalog No. PIPA520614

Description

A suggested positive control is A-20 cell lysate. PA5-20614 can be used with blocking peptide PEP-0734.

ZBRK1 is a member of the Kruppel-associated box-zinc finger protein (KRAB-ZFP) protein family of transcriptional repressors. ZBRK1 has been shown to not only be up-regulated in senescent fibroblasts but also interacts with BRCA1, a transcriptional regulator with tumor suppressor activity. ZBRK1 binds to a specific sequence within the GADD45 gene, supporting the assembly of a nuclear complex containing BRCA1 and repressing its transcription. Recent experiments demonstrate that ZBRK1 can homo-oligomerize in vitro and in vivo through a C-terminal transcriptional repression domain (CTRD), and this oligomerization facilitates the ZBRK1-directed transcriptional repression through ZBRK1 response elements. These results suggest that higher order ZBRK1 oligomers may assemble through both protein-DNA and CTRD-dependent protein-protein interactions.

Specifications

• Antigen: ZNF350
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZNF350
• Gene Alias: KRAB zinc finger protein ZFQR; ZBRK1; ZFQR; Zinc finger and BRCA1-interacting protein with a KRAB domain 1; zinc finger protein 350; Zinc finger protein ZBRK1; zinc-finger protein ZBRK1; ZNF350
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 59348
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q9GZX5
• Gene Symbols: ZNF350
• Immunogen: A 20 amino acid peptide near the carboxy terminus of the human ZBRK1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG