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Invitrogen™ ZNF451 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA569000

Catalog No. PIPA569000


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Description

Description

This target displays homology in the following species: Cow: 93%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 87%; Rat: 100%.

E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation. Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483). [UniProt].
TRUSTED_SUSTAINABILITY
Specifications

Specifications

ZNF451
Polyclonal
Unconjugated
ZNF451
4930515K21Rik; 4933435G09Rik; AI596398; Coactivator for steroid receptors; COASTER; dJ417I1.1; E3 SUMO-protein ligase ZNF451; E3 SUMO-protein ligase ZNF451; zinc finger protein 451; E3 SUMO-protein transferase ZNF451; KIAA0576; Kiaa0576-hp; KIAA1702; mKIAA1702; Zfp451; Zinc finger protein 451; Zinc finger protein 451-like protein; Znf451
Rabbit
Affinity Chromatography
RUO
26036
-20°C, Avoid Freeze/Thaw Cycles
Liquid
Western Blot
0.5 mg/mL
PBS with 2% sucrose and 0.09% sodium azide
Q9Y4E5
ZNF451
synthetic peptide directed towards the C terminal region of human ZNF451.
100 μL
Primary
Human
Antibody
IgG
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