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Invitrogen™ ZNF451 Polyclonal Antibody
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Catalog No. PIPA5116621
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100 μL
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Catalog No. Quantity
PIPA5116621 100 μL
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Catalog No. PIPA5116621 Supplier Invitrogen™ Supplier No. PA5116621
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Description

Rabbit Polyclonal Antibody

Cellular location: Nucleus Immunogen sequence: SSPRGKWQCR ICEDMFDSQE YVKQHCMSLA SHKFHRYSCA HCRKPFHKIE TLYRHCQDEH DNEIKIKYFC GLCDLIFNVE EAFLSHYEEH HSIDYVFVSE KTETSIKTED DFPVIETSNQ LTCGCRESYI CKVNRKEDYS RCLQIMLDKG KLWFRCSLCS ATAQNLTDMN THIHQVHKEK SDEEEQQYVI KCGTCTKAFH DPESAQQHFH RKHCFLQKPS VAHFGSEKSN LYKFTASASH TERKLKQAIN YSKSLDMEKG VENDLSYQNI EEEIVELPDL DYLRTMTHIV FVDFDNWSNF F.

E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation. Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZNF451
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.52 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene ZNF451
Gene Accession No. Q8C0P7, Q9Y4E5
Gene Alias 4930515K21Rik; 4933435G09Rik; AI596398; Coactivator for steroid receptors; COASTER; dJ417I1.1; E3 SUMO-protein ligase ZNF451; E3 SUMO-protein ligase ZNF451; zinc finger protein 451; E3 SUMO-protein transferase ZNF451; KIAA0576; Kiaa0576-hp; KIAA1702; mKIAA1702; Zfp451; Zinc finger protein 451; Zinc finger protein 451-like protein; Znf451
Gene Symbols Zfp451, ZNF451
Host Species Rabbit
Immunogen Recombinant protein (or fragment).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26036, 316312, 98403
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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