ZNF451 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA572615

Catalog No. PIPA572615

Description

E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site ′Lys-11′ (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at ′Lys-9′ (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483).

Specifications

• Antigen: ZNF451
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZNF451
• Gene Alias: Zinc finger protein 451; Coactivator for steroid receptors; ZNF451; COASTER; KIAA0576; KIAA1702
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 26036
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1.4 mg/mL
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: Q9Y4E5
• Gene Symbols: ZNF451
• Immunogen: KLH conjugated synthetic peptide between 81-110 amino acids from the N-terminal region of human ZNF451
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG