Invitrogen™ ZNF496 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5144735

Catalog No. FEPA5144735

Description

Immunogen sequence: SYVCPNCGKI FRWRVNFIRH LRSRREQEKP HECSVCGELF SDSEDLDGHL ESHEAQKPYR CGACGKSFRL NSHLLSHRRI HLQPDRLQPV EKREQAASED ADKGPKEPLE NGKAKLSFQC CECGKAFQRH DHLARHRSHF HLKD Antigen sequence identity: Mouse 78%; Rat 74%.

ZNF496 contains a SCAN box, a KRAB-A domain, and four consensus C2H2-type zinc fingers preceded by a unique finger derivative, referred to herein as the C2HR motif. The C2HR motif functions to mediate protein-protein interaction with the cysteine-rich (C5HCH) domain of NSD1 in a Zn(II)-dependent fashion, and when tethered to RNA polymerase II promoters, represses transcription in an NSD1-dependent manner. ZNF496 contains a novel type of zinc finger motif that functions as a docking site for NSD1 and is more than just a degenerate evolutionary remnant of a C2H2 motif.

Specifications

• Antigen: ZNF496
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZNF496
• Gene Alias: MGC15548; NIZP1; Nizp11; NSD1 (nuclear receptor binding SET-domain containing 1)-interacting zinc finger protein 1; NSD1-interacting zinc finger protein 1; Zfp496; zinc finger protein 496; Zinc finger protein with KRAB and SCAN domains 17; zinc finger with KRAB and SCAN domains 17; Zkscan17; ZNF496; ZSCAN49
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 84838
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid
• Isotype: IgG

• Applications: Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96IT1
• Gene Symbols: ZNF496
• Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 405-548. Recombinant protein control fragment (Product #RP-109712).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Format: Liquid