Invitrogen™ ZNF521 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA534388

Catalog No. PIPA534388

Description

A suggested positive control is Hela cell lysate. PA5-34388 can be used with blocking peptide PEP-1431.

The zinc finger protein 521 (ZNF521) is a transcription factor containing an N-terminal transcriptional repressor motif and 30 zinc finger domains. It plays a role in both erythroid cell and osteoblast differentiation during development, inhibiting the activities of early B-cell factor 1 (EBF1) in erythroid cells and Runx2 in osteoblast precursors. ZFP521 binds to both Runx2 and histone deacetylase 3 (HDAC3), promotes their association and antagonizes Runx2 transcriptional activity in a HDAC3-dependent manner, thereby regulating osteoblast differentiation, skeletal development, and bone homeostasis.

Specifications

• Antigen: ZNF521
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZNF521
• Gene Alias: B930086A16Rik; early hematopoietic zinc finger protein; Ecotropic viral integration site 3 protein; EHZF; Evi3; LIP3; LYST-interacting protein 3; Zfp521; Zinc finger protein 521; Znf521
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 25925
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q96K83
• Gene Symbols: ZNF521
• Immunogen: An 18 amino acid synthetic peptide near the amino terminus of human ZNF521.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG