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Invitrogen™ ZNF536 Polyclonal Antibody
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Catalog No. PIPA524338
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400 μL
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Catalog No. Quantity
PIPA524338 400 μL
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Catalog No. PIPA524338 Supplier Invitrogen™ Supplier No. PA524338
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Description

Rabbit Polyclonal Antibody

ZNF536 Polyclonal Antibody for Western Blot, IHC (P), Flow

ZNF536 is a recently identified zinc-finger protein that is expressed primarily in the developing nervous system and the cerebral cortex, hippocampus, and hypothalamus. ZNF536 possess ten zinc fingers and interacts with CtBP1, a corepressor for gene transcription. It is most closely related to transcriptional repressor ZNF219. Overexpression of ZNF536 in embryonic stem cells dramatically reduced the mRNA levels of neuronal marker genes such as Pax6, MAP2, and beta-tubulin III following retinoic acid (RA)-induced differentiation, while depletion of ZNF536 via RNAi resulted in elevated mRNA levels of these genes, indicating its role in inhibiting neuronal cell differentiation. Overexpression of RA receptor a rescues the inhibitory role of ZNF536, suggesting that ZNF536 might inhibit RA response element-mediated transcriptional activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZNF536
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene ZNF536
Gene Accession No. O15090
Gene Alias 9630010P11Rik; KIAA0390; mKIAA0390; RGD1563363; Zfp536; Zinc finger protein 536; Znf536
Gene Symbols ZNF536
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide between 203-231 amino acids from the N-terminal region of human ZNF536.
Purification Method Antigen affinity chromatography, Protein A
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9745
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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