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Invitrogen™ ZNF536 Polyclonal Antibody
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Catalog No. PIPA520854
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100 μg
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Catalog No. Quantity
PIPA520854 100 μg
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Catalog No. PIPA520854 Supplier Invitrogen™ Supplier No. PA520854
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Description

Rabbit Polyclonal Antibody

A suggested positive control is human brain tissue lysate. PA5-20854 can be used with blocking peptide PEP-0968.

ZNF536 is a recently identified zinc-finger protein that is expressed primarily in the developing nervous system and the cerebral cortex, hippocampus, and hypothalamus. ZNF536 possess ten zinc fingers and interacts with CtBP1, a corepressor for gene transcription. It is most closely related to transcriptional repressor ZNF219. Overexpression of ZNF536 in embryonic stem cells dramatically reduced the mRNA levels of neuronal marker genes such as Pax6, MAP2, and beta-tubulin III following retinoic acid (RA)-induced differentiation, while depletion of ZNF536 via RNAi resulted in elevated mRNA levels of these genes, indicating its role in inhibiting neuronal cell differentiation. Overexpression of RA receptor a rescues the inhibitory role of ZNF536, suggesting that ZNF536 might inhibit RA response element-mediated transcriptional activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZNF536
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene ZNF536
Gene Accession No. O15090, Q8K083
Gene Alias 9630010P11Rik; KIAA0390; mKIAA0390; RGD1563363; Zfp536; Zinc finger protein 536; Znf536
Gene Symbols Zfp536, ZNF536
Host Species Rabbit
Immunogen A 16 amino acid peptide from near the amino terminus of human ZNF536.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 243937, 292820, 9745
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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