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Invitrogen™ ZNF554 Polyclonal Antibody
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Catalog No. PIPA541216
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100 μL
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PIPA541216 100 μL
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Catalog No. PIPA541216 Supplier Invitrogen™ Supplier No. PA541216
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Description

Rabbit Polyclonal Antibody

Peptide sequence: GTPQASCSDW MTVLRNQDST YKKVALQEEP ASGINMIKLI REDGGWKQLE Sequence homology: Human: 100%.

ZNF554, or Zinc Finger Protein 554, is a member of the Kruppel-associated box domain-zinc finger proteins (KRAB-ZNF) subfamily, residing on chromosome 19p13. This region is characterized by a concentration of heterochromatin proteins, which indicates tightly regulated gene expression. ZNF554 is implicated in various cellular processes including transcription regulation and apoptosis. Dysregulation of ZNF554 has been linked to several diseases; notably, its decreased expression is associated with poor prognosis in gliomas, specifically grades III and IV astrocytomas, where it affects the PI3K-Akt signaling pathway. It also plays a role in placental development, with dysfunction contributing to conditions such as fetal growth restriction (FGR). Additionally, ZNF554 transcription is influenced by factors like ZEB1, ZEB2, and hypoxic conditions, with neighboring hypoxia-response elements showing hypermethylation in preeclampsia. This gene's expression can significantly alter the transcriptional landscape, with overexpression leading to the differential regulation of hundreds of genes, underscoring its importance in cellular regulation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZNF554
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene ZNF554
Gene Accession No. Q86TJ5
Gene Alias FLJ34817; Zinc finger protein 554; ZNF554
Gene Symbols ZNF554
Host Species Rabbit
Immunogen Synthetic peptide directed towards the N-terminal of human ZNF554 (aa 141-190).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 115196
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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