Invitrogen™ ZNF554 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA563825

Catalog No. PIPA563825

Description

Immunogen sequence: KNQCTDVGIK EGPLSPAQTS QVTSLSSWTG YLLFQPVASS HLEQREALWI EEKGTPQASC SDWMTVLRNQ DSTYKKVALQ Highest antigen sequence identity to the following orthologs: Mouse - 25%, Rat - 28%.

ZNF554, or Zinc Finger Protein 554, is a member of the Kruppel-associated box domain-zinc finger proteins (KRAB-ZNF) subfamily, residing on chromosome 19p13. This region is characterized by a concentration of heterochromatin proteins, which indicates tightly regulated gene expression. ZNF554 is implicated in various cellular processes including transcription regulation and apoptosis. Dysregulation of ZNF554 has been linked to several diseases; notably, its decreased expression is associated with poor prognosis in gliomas, specifically grades III and IV astrocytomas, where it affects the PI3K-Akt signaling pathway. It also plays a role in placental development, with dysfunction contributing to conditions such as fetal growth restriction (FGR). Additionally, ZNF554 transcription is influenced by factors like ZEB1, ZEB2, and hypoxic conditions, with neighboring hypoxia-response elements showing hypermethylation in preeclampsia. This gene's expression can significantly alter the transcriptional landscape, with overexpression leading to the differential regulation of hundreds of genes, underscoring its importance in cellular regulation.

Specifications

• Antigen: ZNF554
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZNF554
• Gene Alias: FLJ34817; Zinc finger protein 554; ZNF554
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 115196
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q86TJ5
• Gene Symbols: ZNF554
• Immunogen: Recombinant protein corresponding to Human ZNF554. Recombinant protein control fragment (Product #RP-101461).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov