Invitrogen™ ZNF598 Monoclonal Antibody (1E2)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA522840

Catalog No. PIMA522840

Description

Peptide Sequence: SCVLCCGDLE ATALGRCDHP VCYRCSTKMR VLCEQRYCAV CREELRQVVF GKKLPAFATI PIHQLQHEKK YDIYFADGKV YALYRQLLQH ECPRCPELP.

ZNF598 (E3 ubiquitin-protein ligase ZNF598) plays a key role in the ribosome quality control (RQC). RQC is a pathway that takes place when a ribosome has stalled during translation. It is required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40A ribosomal protein RPS10/eS10 and RPS3/uS3. Stalling precludes synthesis of a long poly-lysine tail and initiated the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide.

Specifications

• Antigen: ZNF598
• Classification: Monoclonal
• Concentration: 1.0 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: Q86UK7
• Gene Symbols: ZNF598
• Immunogen: ZNF598 (NP_835461, 28 a.a. ~ 126 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: ELISA, Immunocytochemistry
• Clone: 1E2
• Conjugate: Unconjugated
• Gene: ZNF598
• Gene Alias: BC023040; C6orf149; E3 ubiquitin-protein ligase ZNF598; FLJ00086; ISD11; Ntrap; Zfp598; Zinc finger protein 598; ZNF598
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 90850
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid