Invitrogen™ ZNF598 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA531410

Catalog No. PIPA531410

Description

Recommended positive controls: HL-60, NCI-H929. Predicted reactivity: Human (99%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

ZNF598 (E3 ubiquitin-protein ligase ZNF598) plays a key role in the ribosome quality control (RQC). RQC is a pathway that takes place when a ribosome has stalled during translation. It is required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40A ribosomal protein RPS10/eS10 and RPS3/uS3. Stalling precludes synthesis of a long poly-lysine tail and initiated the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide.

Specifications

• Antigen: ZNF598
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZNF598
• Gene Alias: BC023040; C6orf149; E3 ubiquitin-protein ligase ZNF598; FLJ00086; ISD11; Ntrap; Zfp598; Zinc finger protein 598; ZNF598
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 90850
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q86UK7
• Gene Symbols: ZNF598
• Immunogen: Recombinant protein fragment corresponding to a region within amino acids 533 and 904 of Human ZNF598.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG