ZNF638/NP220 Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

Supplier:  Bethyl Laboratories, Inc A301547AT

Catalog No. 50-156-0666

Description

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Mouse

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. NP220 (Nuclear protein 220), also designated Zinc finger protein 638 (ZNF638) or Cutaneous T-cell lymphoma-associated antigen se33-1, is a 1978 amino acid protein that contains one matrin-type zinc finger and two RRM (RNA recognition motif) domains, suggesting a role in transcriptional regulation. NP220 binds to double-stranded DNA fragments by recognizing clusters of cytidines. NP220 interacts with FHL-2 and is also thought to be phosphorylated by ATM or ATR upon DNA damage. It exists as five isoforms as a result of alternative splicing events. Isoform five of NP220 is a tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL), and in particular in mycosis fungoides patients and in Sezary syndrome patients.

Specifications

• Antigen: ZNF638/NP220
• Classification: Polyclonal
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene Accession No.: Q14966
• Gene Symbols: ZNF638
• Immunogen: Between 225 and 275
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Conjugate: Unconjugated
• Gene: ZNF638
• Gene Alias: Zinc finger protein 638, Cutaneous T-cell lymphoma-associated antigen se33-1, CTCL-associated antigen se33-1, Nuclear protein 220, Zinc finger matrin-like protein, NP220, ZFML
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 27332
• Content And Storage: 4° C
• Form: Liquid