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Invitrogen™ ZNF638 Polyclonal Antibody
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Catalog No. PIPA5101166
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PIPA5101166 100 μL
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Catalog No. PIPA5101166 Supplier Invitrogen™ Supplier No. PA5101166
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total ZNF638.

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. NP220 (Nuclear protein 220), also designated Zinc finger protein 638 (ZNF638) or Cutaneous T-cell lymphoma-associated antigen se33-1, is a 1978 amino acid protein that contains one matrin-type zinc finger and two RRM (RNA recognition motif) domains, suggesting a role in transcriptional regulation. NP220 binds to double-stranded DNA fragments by recognizing clusters of cytidines. NP220 interacts with FHL-2 and is also thought to be phosphorylated by ATM or ATR upon DNA damage. It exists as five isoforms as a result of alternative splicing events. Isoform five of NP220 is a tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL), and in particular in mycosis fungoides patients and in Sezary syndrome patients.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZNF638
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene ZNF638
Gene Accession No. Q14966
Gene Alias AI323587; CTCL tumor antigen se33-1; CTCL-associated antigen se33-1; Cutaneous T-cell lymphoma-associated antigen se33-1; mNP220; Np220; NP220 nuclear protein; nuclear protein 220; Zfml; Zfp638; Zinc finger matrin-like protein; zinc finger protein 638; zinc finger, matrin-like; Znf638
Gene Symbols ZNF638
Host Species Rabbit
Immunogen A synthesized peptide derived from human ZNF638(Accession Q14966), corresponding to amino acid residues T1278-T1328.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27332
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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