Invitrogen™ ZNF839 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA554207

Catalog No. PIPA554207

Description

Immunogen sequence: YKEFEELHKM VKKMCQDYLS SSGLCSQETL EINNDKVAES LGITEFLRKK EIHPDNLGPK HLSRDMDGEQ LEGASSEKRE REAAEEGLAS VKRPRREALS NDTTESLAAN SRGREKPRPL HALAAGTIVS QEEDI Highest antigen sequence identity to the following orthologs: Mouse - 45%, Rat - 51%.

ZNF839, also known as C14orf131, is an 811 amino acid protein that contains one C2H2-type zinc finger. The gene encoding ZNF839 localizes to chromosome 14 and, due to alternative splicing events, four ZNF839 isoforms are expressed. Chromosome 14 contains about 700 genes and 106 million base pairs and makes up about 3.5% of human cellular DNA. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease. The SERPINA1 gene is located on chromosome 14 and when defective leads to the genetic disorder alpha1-antitrypsin deficiency. This disorder is characterized by severe lung complications and liver dysfunction. Notably, the immunoglobulin heavy chain locus is found on chromosome 14 and has been identified as a fusion with the chromosome 19 encoded protein BCL3 in the (14; 19) translocations found in a variety of B cell malignancies.

Specifications

• Antigen: ZNF839
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZNF839
• Gene Alias: C14orf131; renal carcinoma antigen NY-REN-50; Zinc finger protein 839; ZNF839
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55778
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: A8K0R7
• Gene Symbols: ZNF839
• Immunogen: Recombinant protein corresponding to Human ZNF839. Recombinant protein control fragment (Product #RP-89017).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG