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ZNRF1 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501988847
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100 μL
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50-198-8847 100 μL
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Catalog No. 50-198-8847 Supplier Bioss Supplier No. BS9139R
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Description

Rabbit Polyclonal Antibody

E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating ′Lys-48′-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable).

Specifications

Antigen ZNRF1
Applications Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene ZNRF1
Gene Accession No. Q8ND25
Gene Alias B830022L21Rik; BOS_16953; E3 ubiquitin-protein ligase znrf1; LOC100349827; MGC101991; nerve injury gene 283; Nerve injury-induced gene 283 protein; NIN283; peripheral nerve injury protein nin283; ring finger protein 42; RING-type E3 ubiquitin transferase ZNRF1; Rnf42; zgc:77896; zinc and ring finger 1; zinc and ring finger 1, E3 ubiquitin protein ligase; zinc and ring finger protein 1; zinc ring finger protein 1; Zinc/RING finger protein 1; znrf1; Zrfp1
Gene Symbols ZNRF1
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human ZNRF1.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84937
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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