ZNRF2 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-8848	100 μL

Catalog No. 50-198-8848 Supplier Bioss Supplier No. BS9140R

Description

Rabbit Polyclonal Antibody

Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). ZNRF2 (zinc and ring finger 2), also known as RNF202, is a 242 amino acid peripheral membrane protein that contains one RING-type zinc finger and localizes to the lysosome, as well as the endosome and the cell junction. Expressed at high levels in brain tissue, ZNRF2 is thought to function as an E3 ubiquitin-protein ligase that may be involved in the establishment and maintenance of neuronal transmission and plasticity. Upon DNA damage, ZNRF2 is subject to phosphorylation, probably by ATR or ATM.

Specifications

• Antigen: ZNRF2
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: Znrf2
• Gene Accession No.: Q8NHG8
• Gene Alias: 1190002C14Rik; AU044205; D6Ertd365e; E3 ubiquitin-protein ligase ZNRF2; Protein Ells2; RING finger protein 202; RING-type E3 ubiquitin transferase ZNRF2; RNF202; zinc and ring finger 1; zinc and ring finger 2; zinc and ring finger 2, E3 ubiquitin protein ligase; zinc finger/RING finger 2; Zinc/RING finger protein 2; Znrf1; Znrf2
• Gene Symbols: Znrf2
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human ZNRF2.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 223082
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG