Invitrogen™ ZNRF3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120417

Catalog No. PIPA5120417

Description

Positive test controls include: A-549. Immunogen sequence: MHPLGLCNNN DEEDLYEYGW VGVVKLEQPE LDPKPCLTVL GKAKRAVQRG ATAVIFDVSE NPEAIDQLNQ GSEDPLKRPV VYVKGADAIK LMNIVNKQKV A.

The ZNRF3 gene encodes a transmembrane E3 ubiquitin ligase that plays a critical role in regulating the Wnt signaling pathway, which is essential for various biological processes, including embryonic development and cell proliferation. ZNRF3 functions by negatively regulating this pathway through ubiquitination and degradation of Frizzled receptors, thereby suppressing the Wnt signaling. Located on chromosome 22, ZNRF3 acts as a tumor suppressor gene by inhibiting oncogenic Wnt signaling and has been implicated in the formation and progression of several cancers, particularly colorectal cancer. Moreover, ZNRF3 interacts with R-spondin proteins which are known to augment Wnt signaling by targeting ZNRF3 for degradation, thus facilitating cell differentiation and proliferation. Alterations in ZNRF3 expression or mutations can lead to aberrant Wnt signaling, contributing to tumorigenesis. Additionally, ZNRF3's role extends to its participation in lipid metabolism and maintenance of bone homeostasis. It has been studied as a potential therapeutic target due to its central involvement in these regulatory pathways.

Specifications

• Antigen: ZNRF3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZNRF3
• Gene Alias: BK747E2.3; CTA-292E10.6; E3 ubiquitin-protein ligase ZNRF3; Gm1167; KIAA1133; novel C3HC4 type Zinc finger (ring finger); rCG35969-like; RING finger protein 203; RING-type E3 ubiquitin transferase ZNRF3; RNF203; similar to ring finger protein 43; zinc and ring finger 3; zinc/RING finger protein 3; ZNRF3
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 407821, 685487, 84133
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.96 mg/mL
• Formulation: PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene Accession No.: Q5SSZ7, Q9ULT6
• Gene Symbols: ZNRF3
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human ZNRF3 (NP_0011939271).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG