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Invitrogen™ ZO-1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ 402200

Description
40-2200 was used successfully in the immunofluorescence analysis of Zo-1 in MDCK cells.
ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.
Specifications
ZO-1 | |
Polyclonal | |
Unconjugated | |
TJP1 | |
DKFZp686M05161; I79_005485; MGC133289; OTTHUMP00000174520; Tight junction protein 1; tight junction protein 1 (zona occludens 1); tight junction protein ZO-1; Tjp1; zo1; ZO-1; ZO-1 MDCK; zona occludens 1; zona occludens protein 1; zonula occludens 1; zonula occludens 1 protein; zonula occludens protein 1 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
21872, 292994, 403752, 7082 | |
-20°C | |
Liquid |
Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry | |
0.25 mg/mL | |
PBS with 0.1% sodium azide; pH 7.4 | |
O97758, P39447, Q07157 | |
TJP1 | |
Synthetic peptide in the middle region of the ZO-1 protein. | |
100 μg | |
Primary | |
Human, Mouse, Rat, Canine | |
Antibody | |
IgG |
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