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ZO-1 Rabbit anti-Human, CoraLite 594, Polyclonal, Proteintech
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Catalog No. 502257542 Shop All Proteintech Group Inc Products
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50-225-7542 100 μL
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Catalog No. 50-225-7542 Supplier Proteintech Group Inc Supplier No. CL59421773100UL
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Description

Rabbit Polyclonal Antibody

Tight junction (or zonula occludens) form the continuous intercellular barrier between epithelial and endothelial cells, which is required to separate tissue spaces and regulate selective movement of solutes across the epithelium and endothelium (PMID: 20066090). ZO-1 (also known as TJP1) is a peripheral membrane phosphoprotein located on the cytoplasmic face and is expressed in tight junctions of both epithelial and endothelial cells (PMID: 3528172). It binds the transmembrane proteins occludin and the claudins linking them to cytoskeletal actin (PMID: 17418867). ZO-1 belongs to a family of multidomain proteins known as the membrane-associated guanylate kinase homologs (MAGUKs). It is a pivotal tight junction protein and may be involved in signalling mechanisms regulating cell proliferation and differentiation (PMID: 22782886).

Specifications

Antigen ZO-1
Applications Immunofluorescence
Classification Polyclonal
Concentration 1000 μg/mL
Conjugate CoraLite 594
Host Species Rabbit
Quantity 100 μL
Primary or Secondary Primary
Gene ID (Entrez) 7082
Target Species Human
Form Liquid
Isotype IgG
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