ZP2 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Thermo Scientific PA587653
Immunogen sequence: KMTVSLPGPI LLLSDDSSFR GVGSSDLKAS GSSGEKSRSE TGEEVGSRGA MDTKGHKTAG DVGSKAVAAV AAFAGVVATL GFIYYLYEKR TVSNH; Positive Samples: SH-SY5Y, HL-60, SW620, Mouse liver, Rat ovary; Cellular Location: Cell membrane, Single-pass type I membrane protein, extracellular matrix, extracellular spaceThe zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies.
|Recombit fusion protein containing a sequence corresponding to amino acids 651-745 of human ZP2|
|Human, Mouse, Rat|
|Immunofluorescence, Western Blot|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|O54767, P20239, Q05996|
|Antigen Affinity Chromatography|
|22787, 7783, 81828|
|-20° C, Avoid Freeze/Thaw Cycles|
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