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Invitrogen™ ZP3 Polyclonal Antibody
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Catalog No. PIPA541135
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100 μL
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PIPA541135 100 μL
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Catalog No. PIPA541135 Supplier Invitrogen™ Supplier No. PA541135
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Description

Rabbit Polyclonal Antibody

Peptide sequence: NKGDCGTPSH SRRQPHVMSQ WSRSASRNRR HVTEEADVTV GATDLPGQEW Sequence homology: Cow: 100%; Horse: 100%; Human: 100%; Rabbit: 100%; Rat: 90%.

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZP3
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene ZP3
Gene Accession No. P21754
Gene Alias Processed zona pellucida sperm-binding protein 3; Sperm receptor; zona pellucida C; zona pellucida C protein; zona pellucida glycoprotein 3; zona pellucida glycoprotein 3 (sperm receptor); zona pellucida glycoprotein 3 preproprotein; zona pellucida glycoprotein 3A (sperm receptor); zona pellucida glycoprotein 3B; zona pellucida glycoprotein ZP3; zona pellucida glycoprotein ZP3B; zona pellucida protein C; Zona pellucida sperm-binding protein 3; Zp3; Zp-3; ZP3A; ZP3A/ZP3B; ZP3B; Zp-3B; ZPC
Gene Symbols ZP3
Host Species Rabbit
Immunogen Synthetic peptide directed towards the C-terminal of human ZP3.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7784
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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