ZRANB2 Monoclonal Antibody (OTI2E3), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA809526

Catalog No. 50-168-2856

Description

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF265 (Zinc finger protein 265), also known as ZRANB2 (Zinc finger Ran-binding domain-containing protein 2), ZIS, ZIS1 or ZIS2, is a 330 amino acid protein that belongs to the ZRANB2 family. Localized to the nucleus, ZNF265 functions as a splicing factor that is responsible for alternatively splicing Tra-2 beta (transformer-2 beta) transcripts and is thought to interfere with constitutive 5′-splice selection. ZNF265 contains two RanBP2-type zinc fingers through which it conveys its RNA-binding activity. Two isoforms, designated ZIS-1 and ZIS-2, are expressed due to alternative splicing events. Upon DNA damage, ZIS-2 may be phosphorylated by ATM or ATR.

Specifications

• Antigen: ZRANB2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: O95218
• Gene Symbols: ZRANB2
• Immunogen: Human recombit protein fragment corresponding to amino acids 95-320 of human ZRANB2 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin)
• Clone: OTI2E3
• Conjugate: Unconjugated
• Gene: ZRANB2
• Gene Alias: ZIS, ZIS1, ZIS2, ZNF265
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9406
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid