ZRANB2 Mouse anti-Human, Clone: OTI2E3, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF809526

Catalog No. 50-166-9559

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF265 (Zinc finger protein 265), also known as ZRANB2 (Zinc finger Ran-binding domain-containing protein 2), ZIS, ZIS1 or ZIS2, is a 330 amino acid protein that belongs to the ZRANB2 family. Localized to the nucleus, ZNF265 functions as a splicing factor that is responsible for alternatively splicing Tra-2 beta (transformer-2 beta) transcripts and is thought to interfere with constitutive 5′-splice selection. ZNF265 contains two RanBP2-type zinc fingers through which it conveys its RNA-binding activity. Two isoforms, designated ZIS-1 and ZIS-2, are expressed due to alternative splicing events. Upon DNA damage, ZIS-2 may be phosphorylated by ATM or ATR.

Specifications

• Antigen: ZRANB2
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: ZRANB2
• Gene Alias: ZIS, ZIS1, ZIS2, ZNF265
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9406
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin)
• Clone: OTI2E3
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: O95218
• Gene Symbols: ZRANB2
• Immunogen: Human recombit protein fragment corresponding to amino acids 95-320 of human ZRANB2 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1