Invitrogen™ ZRANB2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA541116

Catalog No. PIPA541116

Description

Peptide sequence: EDKESEGEEE DEDEDLSKYK LDEDEDEDDA DLSKYNLDAS EEEDSNKKKS Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 92%.

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF265 (Zinc finger protein 265), also known as ZRANB2 (Zinc finger Ran-binding domain-containing protein 2), ZIS, ZIS1 or ZIS2, is a 330 amino acid protein that belongs to the ZRANB2 family. Localized to the nucleus, ZNF265 functions as a splicing factor that is responsible for alternatively splicing Tra-2 beta (transformer-2 beta) transcripts and is thought to interfere with constitutive 5'-splice selection. ZNF265 contains two RanBP2-type zinc fingers through which it conveys its RNA-binding activity. Two isoforms, designated ZIS-1 and ZIS-2, are expressed due to alternative splicing events. Upon DNA damage, ZIS-2 may be phosphorylated by ATM or ATR.

Specifications

• Antigen: ZRANB2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Zranb2
• Gene Alias: AI227013; DKFZp686J1831; DKFZp686N09117; wu:fa96h03; Zfp265; zgc:56597; zinc finger protein 265; Zinc finger Ran-binding domain-containing protein 2; Zinc finger Ran-binding domain-containing protein 2-like protein; zinc finger RANBP2-type containing 2; zinc finger, RAN-binding domain containing 2; zinc finger, splicing; zinc-finger protein 265; zinc-finger, splicing; ZIS; ZIS1; ZIS2; Znf265; ZRANB2
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9406
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: O95218
• Gene Symbols: Zranb2
• Immunogen: Synthetic peptide directed towards the middle region of human ZRANB2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG