Invitrogen™ ZRANB3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA571320

Catalog No. PIPA571320

Description

This target displays homology in the following species: Cow: 93%; Dog: 83%; Horse: 88%; Human: 100%; Pig: 93%.

DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events (PubMed:21078962, PubMed:22704558, PubMed:22705370, PubMed:22759634, PubMed:26884333). Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase (PubMed:22759634). In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks (PubMed:22705370, PubMed:22704558). [UniProt].

Specifications

• Antigen: ZRANB3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZRANB3
• Gene Alias: 4933425L19Rik; AH2; AI316834; Annealing helicase 2; C730006D09; DNA annealing helicase and endonuclease ZRANB3; DNA annealing helicase ZRANB3; Endonuclease ZRANB3; RGD1564952; Zinc finger Ran-binding domain-containing protein 3; zinc finger RANBP2-type containing 3; zinc finger, RAN-binding domain containing 3; ZRANB3
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 84083
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q5FWF4
• Gene Symbols: ZRANB3
• Immunogen: synthetic peptide directed towards the C-terminal region of human ZRANB3.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG