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Invitrogen™ ZRANB3 Polyclonal Antibody
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Catalog No. PIPA597227
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100 μL
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PIPA597227 100 μL
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Catalog No. PIPA597227 Supplier Invitrogen™ Supplier No. PA597227
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Description

Rabbit Polyclonal Antibody

Positive Samples: HeLa, Raji, Jurkat, 293T, Mouse liver, Mouse heart, Mouse brain, Rat liver; Cellular Location: Chromosome, Nucleus.

DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events (PubMed:21078962, PubMed:22704558, PubMed:22705370, PubMed:22759634, PubMed:26884333). Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase (PubMed:22759634). In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks (PubMed:22705370, PubMed:22704558). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZRANB3
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.14 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene ZRANB3
Gene Accession No. Q5FWF4, Q6NZP1
Gene Alias 4933425L19Rik; AH2; AI316834; Annealing helicase 2; C730006D09; DNA annealing helicase and endonuclease ZRANB3; DNA annealing helicase ZRANB3; Endonuclease ZRANB3; RGD1564952; Zinc finger Ran-binding domain-containing protein 3; zinc finger RANBP2-type containing 3; zinc finger, RAN-binding domain containing 3; ZRANB3
Gene Symbols ZRANB3
Host Species Rabbit
Immunogen Recombinant protein (or fragment).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 226409, 304761, 84083
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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