ZSCAN4 Monoclonal Antibody (OTI1E7), TrueMAB™, OriGene

Catalog No.	Quantity
50-167-8310	100 μL

Catalog No. 50-167-8310 Supplier OriGene Supplier No. TA800425

Description

Mouse Monoclonal Antibody

Zytotic genome activation (ZGA) is the first and most critical transition event from the maternal genetic to the embryonic genetic program and the major burst of ZGA occurs only in the late 2-cell stage. ZSCAN4 encodes a SCAN domain and four zinc finger domains and is expressed in late 2-cell embryos and embryonic stem cells. Loss-of-function studies using siRNA shows delays in the progression from the 2-cell to the 4-cell stage and subsequent embryo development. ZSCAN4 plays an important role in the preimplantation development. Also, ZSCAN4 is involved in telomere maintece and long term genomic stability in ES cells, suggesting that ZSCAN4 may be of critical importance in maintaining pluripotency in replicating stem cells.

Specifications

• Antigen: ZSCAN4
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI1E7
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: ZSCAN4
• Gene Accession No.: Q8NAM6
• Gene Alias: ZNF494
• Gene Symbols: ZSCAN4
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 164-433 of human ZSCAN4 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 201516
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1